Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death
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منابع مشابه
Inhibition of Stearoyl-CoA Desaturase 1 Expression Induces CHOP-Dependent Cell Death in Human Cancer Cells
BACKGROUND Cancer cells present a sustained de novo fatty acid synthesis with an increase of saturated and monounsaturated fatty acid (MUFA) production. This change in fatty acid metabolism is associated with overexpression of stearoyl-CoA desaturase 1 (Scd1), which catalyses the transformation of saturated fatty acids into monounsaturated fatty acids (e.g., oleic acid). Several reports demonst...
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Stearoyl-CoA desaturase 1 (SCD1) is an established molecular target in many primary tumors including breast, lung, pancreatic, colon and hepatocellular carcinomas. However, its potential role in supporting endometrial cancer growth and progression has not yet been determined. In this study, we evaluated the value of SCD1 as a candidate therapeutic target in human endometrial cancer. Compared wi...
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متن کامل1 MEMBRANE TOPOLOGY OF MOUSE STEAROYL - COA DESATURASE 1 Weng
MEMBRANE TOPOLOGY OF MOUSE STEAROYL-COA DESATURASE 1 Weng Chi Man*, Makoto Miyazaki*, Kiki Chu*, and James M. Ntambi* From the Departments of *Biochemistry and ¶Nutritional Sciences, University of Wisconsin-Madison, Madison, WI 53706 Running Title: Mouse SCD1 Topology Address correspondence to: James M. Ntambi, Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madi...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2019
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-19-0369